For Research Use Only. This product is supplied exclusively for laboratory research and is not intended for human or veterinary use.
MOTS-c Research Peptide
MOTS-c (mitochondrial ORF of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide. ZENTRA supplies it as high-purity lyophilised research material in 10mg and 40mg formats for controlled laboratory and analytical applications.
Published research identifies the human MOTS- c sequence as MRWQEMGYIFYPRKLR. The peptide is encoded within a short open reading frame in mitochondrial 12S rRNA and has been investigated in experimental models of cellular bioenergetics, metabolic signalling, stress adaptation and skeletal-muscle homeostasis.
Technical Specifications
| Product | MOTS- c |
|---|---|
| Full name | Mitochondrial ORF of the Twelve S rRNA type-c |
| Peptide length | 16 amino acids |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-ArgMRWQEMGYIFYPRKLR |
| Molecular weight | Approximately 2174.6 g/mol |
| Purity | Above 99% by third-party HPLC testing |
| Physical form | White lyophilised powder |
| Available formats | 10mg and 40mg |
| Intended use | Laboratory research and analytical use only |
Independent Batch Testing
Every current ZENTRA MOTS- c batch is independently tested and records an HPLC purity result above 99%. The batch number on the product label can be checked against the corresponding third-party report in our Batch Verification and COA Centre. Researchers should consult the individual report for the exact analytical methods, purity result and testing date for their supplied batch.
MOTS- c Research Context
The original 2015 research identified MOTS-c as a mitochondrial-derived peptide and investigated its effects on cellular glucose metabolism, AMPK-related signalling and metabolic homeostasis in cultured cells and mouse models. A 2018 cell study found that MOTS-c could move to the nucleus during metabolic stress and influence adaptive nuclear gene expression.
A 2021 study reported that acute exercise increased endogenous MOTS- c expression in human skeletal muscle and circulation in a small experimental cohort. The same paper examined age-dependent physical capacity and skeletal-muscle homeostasis in mice. These findings are useful research signals, but they do not establish a therapeutic effect, safety profile or approved use in humans.
The evidence base remains predominantly preclinical, with limited human observational and experimental data. ZENTRA supplies MOTS-c solely as a research compound and does not provide medical, therapeutic or dosing guidance.
Storage and Handling
For long-term storage, keep unopened lyophilised material at approximately -20°C. For short-term laboratory storage, maintain at 2-8°C. Protect the vial from light, moisture and repeated temperature changes. Use appropriate laboratory handling procedures and consult your institutional protocol before preparing research solutions.
MOTS-c Research FAQs
What is MOTS- c?
MOTS- c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It is studied as a signalling molecule involved in cellular energy and stress-response pathways.
What is the MOTS- c sequence and molecular weight?
The published human sequence is MRWQEMGYIFYPRKLR. Its molecular weight is approximately 2174.6 g/mol.
Which MOTS- c sizes are available?
This product is available as 10mg and 40mg of lyophilised research material. Select the required format before adding it to the basket.
How is MOTS- c purity verified?
Every current batch is tested by an independent laboratory using HPLC and records a purity result above 99%. The matching report can be found using the batch number printed on the product label.
What research areas have examined MOTS- c?
Published studies have investigated mitochondrial signalling, cellular bioenergetics, AMPK-related pathways, metabolic-stress responses and skeletal-muscle homeostasis. Most evidence comes from cell and animal models; human evidence remains limited.
Is this product intended for human or veterinary use?
No. ZENTRA MOTS-c is supplied strictly for laboratory research and analytical purposes. It is not intended for human consumption, veterinary use, diagnosis or treatment.
Selected Primary Research
- The mitochondrial-derived peptide MOTS- c promotes metabolic homeostasis and reduces obesity and insulin resistance.
- The mitochondrial-encoded peptide MOTS translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress.
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.
Research Resources
- MOTS-c Batch Verification and COAs
- Research Peptide Storage Guide
- Lyophilised Peptide Reconstitution Guide
- What Are Research Peptides?
- Browse All Research Peptides
For research use only. Not for human or veterinary use.
